Correction: Random Mutagenesis Identifies a C-Terminal Region of YopD Important for Yersinia Type III Secretion Function
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Random Mutagenesis Identifies a C-Terminal Region of YopD Important for Yersinia Type III Secretion Function
A common virulence mechanism among bacterial pathogens is the use of specialized secretion systems that deliver virulence proteins through a translocation channel inserted in the host cell membrane. During Yersinia infection, the host recognizes the type III secretion system mounting a pro-inflammatory response. However, soon after they are translocated, the effectors efficiently counteract tha...
متن کاملImpact of the N-terminal secretor domain on YopD translocator function in Yersinia pseudotuberculosis type III secretion.
Type III secretion systems (T3SSs) secrete needle components, pore-forming translocators, and the translocated effectors. In part, effector recognition by a T3SS involves their N-terminal amino acids and their 5' mRNA. To investigate whether similar molecular constraints influence translocator secretion, we scrutinized this region within YopD from Yersinia pseudotuberculosis. Mutations in the 5...
متن کاملThe YopD translocator of Yersinia pseudotuberculosis is a multifunctional protein comprised of discrete domains.
To establish an infection, Yersinia pseudotuberculosis utilizes a plasmid-encoded type III translocon to microinject several anti-host Yop effectors into the cytosol of target eukaryotic cells. YopD has been implicated in several key steps during Yop effector translocation, including maintenance of yop regulatory control and pore formation in the target cell membrane through which effectors tra...
متن کاملYersinia pestis YopD 150-287 fragment is partially unfolded in the native state.
Yersinia pestis, a human and animal pathogen, uses the type III secretion system (T3SS) for delivering virulence factors and effectors into the host cells. The system is conserved in animal pathogens and is hypothesized to deliver the virulence factors directly from bacterial to mammalian cells through a pore composed of YopB and YopD translocation proteins. The YopB and YopD translocator prote...
متن کاملYopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.
Yersinia pestis produces a set of virulence proteins (Yops and LcrV) that are expressed at high levels and secreted by a type III secretion system (Ysc) upon bacterium-host cell contact, and four of the Yops are vectorially translocated into eukaryotic cells. YopD, YopB, and YopK are required for the translocation process. In vitro, induction and secretion occur at 37 degrees C in the absence o...
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